Alkaloid metabolic process

Across TCGA patient cohorts, RNA activity of the Alkaloid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TACC2_S41, EPB41L2_S386, and ITGA11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alkaloid metabolic process activity versus TACC2_S41 in CCRCC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TACC2_S41 →	+0.765	+0.093	.008	.006	3	6
BRCA	EPB41L2_S386 →	+0.570	+0.079	<.001	<.001	3	5
OV	ITGA11 →	+0.571	+0.089	<.001	<.001	3	5
OV	LUZP1_T679 →	+0.890	+0.134	.005	.005	3	5
CCRCC	NUMB_T436 →	-0.212	-0.085	<.001	<.001	3	5
LUAD	SMTN →	+0.337	+0.096	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009820 vs TACC2_S41 — CCRCC

Explore this scatter interactively →