Alkaloid metabolic process

Across TCGA patient cohorts, RNA activity of the Alkaloid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENG, SGCA, and TMOD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alkaloid metabolic process activity versus ENG in HNSC (Pearson r = 0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ENG →	+0.461	+0.128	.001	.002	3	3
HNSC	SGCA →	+1.262	+0.117	.001	.002	3	3
HNSC	TMOD1 →	+1.291	+0.149	<.001	<.001	3	3
HNSC	NOTCH1 →	+0.462	+0.117	.009	.005	3	3
HNSC	ABCC9 →	+0.641	+0.113	<.001	.007	3	3
HNSC	GAS7 →	+0.452	+0.114	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009820 vs ENG — HNSC

Explore this scatter interactively →