Alkaloid metabolic process

Across TCGA cell cohorts, RNA activity of the Alkaloid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAMPT, PITRM1, and TOP3B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alkaloid metabolic process activity versus NAMPT in BREAST (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NAMPT →	+2.322	+1.403	.001	<.001	3	3
LUNG_NSCLC_LUAD	PITRM1 →	+0.942	+0.596	.001	.001	3	3
PANCREAS	TOP3B →	+1.153	+1.928	<.001	.001	3	3
PANCREAS	PON3 →	-2.719	-1.417	.003	.003	3	3
BREAST	CENPI →	+1.031	+1.078	.001	.004	3	3
BREAST	ETS1 →	+3.711	+1.247	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009820 vs NAMPT — BREAST

Explore this scatter interactively →