Flavonoid metabolic process

Across TCGA patient cohorts, RNA activity of the Flavonoid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPR, AKR1C3, and GSTM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Flavonoid metabolic process activity versus SPR in LSCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPR →	+0.448	+0.561	<.001	<.001	3	6
LSCC	AKR1C3 →	+1.082	+0.603	<.001	<.001	3	6
LSCC	GSTM2 →	+0.914	+0.500	<.001	<.001	3	6
GBM	NOL8_S660 →	-0.353	-0.600	.007	.002	3	5
GBM	PLCD1 →	+0.565	+0.564	<.001	.001	3	5
LUAD	ADD1 →	+0.268	+0.993	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009812 vs SPR — LSCC

Explore this scatter interactively →