Flavonoid metabolic process

Across TCGA patient cohorts, RNA activity of the Flavonoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYBB2P1, TREML3P, and ALDH3A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Flavonoid metabolic process activity versus CRYBB2P1 in PDAC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CRYBB2P1 →	+0.276	+0.285	.006	.003	3	3
LSCC	TREML3P →	+0.852	+0.522	.001	.001	3	3
LSCC	ALDH3A1 →	+2.791	+0.738	<.001	<.001	3	3
LSCC	UGT1A6 →	+1.280	+0.532	.002	.003	3	3
LSCC	NQO1 →	+1.636	+0.690	<.001	<.001	3	3
LSCC	CYP4F3 →	+2.261	+0.660	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009812 vs CRYBB2P1 — PDAC

Explore this scatter interactively →