Flavonoid metabolic process

Across TCGA patient cohorts, RNA activity of the Flavonoid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SULT1A1, UGT1A10, and SYNPO_S536, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Flavonoid metabolic process activity versus SULT1A1 in UCEC (Pearson r = 0.72).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SULT1A1 →	+2.013	+0.921	<.001	.006	3	3
LUAD	UGT1A10 →	+3.524	+2.095	.001	.001	1	5
LUAD	SYNPO_S536 →	-0.620	-1.377	<.001	<.001	3	2
COAD	TAGLN_Y193 →	-0.619	-0.330	<.001	<.001	3	2
HNSC	CUL9 →	+0.238	+0.620	<.001	.001	3	2
GBM	SAFB2 →	-0.343	-0.636	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009812 vs SULT1A1 — UCEC

Explore this scatter interactively →