Flavonoid metabolic process

Across TCGA cell cohorts, RNA activity of the Flavonoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXN2, MPP2, and CDC25B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TXN2 grouped by Flavonoid metabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TXN2 →	+0.449	+1.007	.001	.005	3	4
CNS	MPP2 →	+0.962	+0.992	.001	<.001	3	4
BREAST	CDC25B →	+0.721	+0.557	.002	.001	3	3
BREAST	POFUT1 →	+0.515	+0.567	.009	.001	3	3
BREAST	AGR2 →	-3.547	-0.734	.004	.001	3	3
BREAST	KRT18 →	-1.268	-0.583	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TXN2 by Flavonoid metabolic process activity — KIDNEY

Explore this box plot interactively →