Flavonoid metabolic process

Across TCGA cell cohorts, RNA activity of the Flavonoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SULT1A3, SULT1A1, and SULT1A2, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Flavonoid metabolic process activity versus SULT1A3 in OESOPHAGUS (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SULT1A3 →	+2.037	+1.428	<.001	<.001	3	18
LIVER	SULT1A1 →	+4.425	+1.172	<.001	.001	3	16
PANCREAS	SULT1A2 →	+1.833	+1.036	<.001	<.001	3	11
OESOPHAGUS	ATG7 →	-1.227	-1.107	<.001	.001	3	10
OESOPHAGUS	YWHAQ →	-1.162	-1.092	<.001	.006	3	9
OVARY	FRMD6 →	-2.199	-0.998	.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009812 vs SULT1A3 — OESOPHAGUS

Explore this scatter interactively →