Axis specification

Across TCGA patient cohorts, RNA activity of the Axis specification pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNFAIP8L2, PTPN6, and RNF213, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axis specification activity versus TNFAIP8L2 in LSCC (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TNFAIP8L2 →	-0.379	-0.043	<.001	<.001	3	7
GBM	PTPN6 →	-0.485	-0.035	.001	.001	3	7
LSCC	RNF213 →	-0.416	-0.040	<.001	<.001	3	7
GBM	CSTA →	-0.586	-0.034	<.001	<.001	3	7
PDAC	CYBB →	-0.629	-0.037	.006	.001	3	7
PDAC	HK3 →	-0.422	-0.026	.006	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009798 vs TNFAIP8L2 — LSCC

Explore this scatter interactively →