Axis specification

Across TCGA patient cohorts, RNA activity of the Axis specification pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUDT12, PLA2G12A, and CAPN7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axis specification activity versus NUDT12 in BRCA (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NUDT12 →	+0.750	+0.521	.007	.004	3	4
LUAD	PLA2G12A →	+0.437	+0.318	<.001	.007	3	4
LUAD	CAPN7 →	+0.152	+0.271	.006	.001	3	4
BRCA	IDNK →	+0.749	+0.519	<.001	.004	3	4
CCRCC	C3orf49 →	+0.418	+0.280	<.001	.006	3	4
BRCA	MBLAC2 →	+0.539	+0.576	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009798 vs NUDT12 — BRCA

Explore this scatter interactively →