Axis specification

Across TCGA cell cohorts, RNA activity of the Axis specification pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPAST, DNLZ, and RER1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPAST grouped by Axis specification-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPAST →	+0.854	+1.489	.001	<.001	3	4
SKIN	DNLZ →	-0.447	-0.817	<.001	<.001	3	4
BLOOD_Lymphoma	RER1 →	-1.000	-1.919	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SEC61A1 →	-0.644	-1.399	.005	.003	3	4
LUNG_NSCLC_LUAD	MAGI3 →	+0.601	+0.836	.005	.001	3	4
KIDNEY	SUPT4H1 →	-0.585	-1.420	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPAST by Axis specification activity — BLOOD_Leukemia

Explore this box plot interactively →