Axis specification

Across TCGA cell cohorts, RNA activity of the Axis specification pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAAF5, POLL, and SLIT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAAF5 grouped by Axis specification-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DNAAF5 →	-0.180	-1.957	.002	<.001	3	4
LIVER	POLL →	-0.216	-1.783	.001	<.001	3	4
BLOOD_Leukemia	SLIT1 →	-0.270	-1.691	.008	<.001	3	4
LARGE_INTESTINE	USP4 →	+0.173	+0.882	.001	.009	3	3
LARGE_INTESTINE	LCN6 →	-0.196	-1.383	.002	.005	3	3
LIVER	PIK3R3 →	+0.260	+1.783	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAAF5 by Axis specification activity — OVARY

Explore this box plot interactively →