Axis specification

Across TCGA cell cohorts, RNA activity of the Axis specification pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, SLC44A2, and PRDM8, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axis specification activity versus BASP1 in LUNG_SCLC (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BASP1 →	+3.978	+1.313	<.001	<.001	3	11
BLOOD_Leukemia	SLC44A2 →	-1.921	-0.953	.009	.003	3	5
SOFT_TISSUE	PRDM8 →	+2.811	+1.576	<.001	<.001	3	5
LIVER	CPLX1 →	-2.495	-1.844	<.001	.001	3	5
BREAST	TRPC1 →	+1.135	+1.190	<.001	<.001	3	5
LIVER	RFTN1 →	+3.332	+1.861	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009798 vs BASP1 — LUNG_SCLC

Explore this scatter interactively →