Post-embryonic development

Across TCGA patient cohorts, RNA activity of the Post-embryonic development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, KLK7, and PDZK1P1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Post-embryonic development activity versus ANXA1 in UCEC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANXA1 →	-1.277	-0.601	<.001	.008	3	3
BRCA	KLK7 →	-1.423	-0.527	.001	.003	3	3
BRCA	PDZK1P1 →	+0.271	+0.424	.007	.008	3	3
BRCA	RPL35AP23 →	+0.149	+0.388	.006	.004	3	3
BRCA	MIR6865 →	+0.874	+0.459	<.001	<.001	3	3
HNSC	CLEC1B →	+0.497	+0.311	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009791 vs ANXA1 — UCEC

Explore this scatter interactively →