Post-embryonic development

Across TCGA cell cohorts, RNA activity of the Post-embryonic development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGF2R, BTG2, and MACC1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Post-embryonic development activity versus IGF2R in BLOOD_Myeloma (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	IGF2R →	+1.602	+1.424	<.001	.008	3	7
LUNG_SCLC	BTG2 →	-1.956	-1.306	.001	<.001	3	5
OESOPHAGUS	MACC1 →	-2.250	-1.227	<.001	.001	2	5
OESOPHAGUS	SEMA4A →	-2.135	-0.962	<.001	.002	3	4
BLOOD_Leukemia	NR6A1 →	-0.758	-1.223	.005	<.001	3	4
CNS	SFXN2 →	-1.407	-1.553	.007	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009791 vs IGF2R — BLOOD_Myeloma

Explore this scatter interactively →