Carbohydrate mediated signaling

Across TCGA patient cohorts, RNA activity of the Carbohydrate mediated signaling pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFTN1, CAPZB, and COLEC12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate mediated signaling activity versus RFTN1 in LSCC (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFTN1 →	+0.458	+0.086	<.001	<.001	3	6
GBM	CAPZB →	+0.176	+0.074	.003	.002	3	6
LSCC	COLEC12 →	+0.582	+0.089	<.001	<.001	3	6
LSCC	DOCK11 →	+0.362	+0.110	<.001	<.001	3	6
COAD	PLXDC2 →	+0.412	+0.051	<.001	<.001	3	6
BRCA	RASA3_S809 →	+0.624	+0.057	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009756 vs RFTN1 — LSCC

Explore this scatter interactively →