Carbohydrate mediated signaling

Across TCGA patient cohorts, RNA activity of the Carbohydrate mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATAT1, TMEM81, and C12orf73, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate mediated signaling activity versus ATAT1 in GBM (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ATAT1 →	+0.411	+0.502	<.001	<.001	3	5
LUAD	TMEM81 →	+0.396	+0.557	.001	.002	3	4
UCEC	C12orf73 →	+0.378	+0.536	<.001	.002	3	4
LUAD	SNAP47-AS1 →	+0.289	+0.502	.002	.006	3	4
UCEC	CEP72 →	+0.523	+0.288	.002	.008	3	4
UCEC	ZNF670-ZNF695 →	+0.528	+0.475	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009756 vs ATAT1 — GBM

Explore this scatter interactively →