Carbohydrate mediated signaling

Across TCGA cell cohorts, RNA activity of the Carbohydrate mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDN1, TLE1, and PITX3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MDN1 grouped by Carbohydrate mediated signaling-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MDN1 →	+1.288	+1.550	<.001	<.001	3	5
BONE	TLE1 →	-2.444	-1.184	<.001	<.001	3	5
LUNG_NSCLC_LUAD	PITX3 →	+0.143	+0.360	.007	.006	3	4
SKIN	SKAP1 →	-0.300	-0.778	.002	.003	3	3
BONE	ANKH →	-2.436	-1.184	.001	<.001	3	3
SKIN	SERPINA3 →	-4.800	-0.876	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MDN1 by Carbohydrate mediated signaling activity — BONE

Explore this box plot interactively →