Carbohydrate mediated signaling

Across TCGA cell cohorts, RNA activity of the Carbohydrate mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USF1, MLXIPL, and NLGN2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate mediated signaling activity versus USF1 in BREAST (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	USF1 →	+0.948	+0.190	<.001	<.001	3	11
URINARY_TRACT	MLXIPL →	-1.941	-0.268	<.001	.002	2	9
SKIN	NLGN2 →	-0.933	-0.210	.002	<.001	3	8
LUNG_NSCLC_LUAD	ANK3 →	-1.102	-0.125	<.001	<.001	3	7
BLOOD_Leukemia	ITGA2B →	-2.507	-0.091	<.001	.001	3	7
BREAST	NKX6-1 →	-1.020	-0.187	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009756 vs USF1 — BREAST

Explore this scatter interactively →