Carbohydrate mediated signaling

Across TCGA cell cohorts, RNA activity of the Carbohydrate mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKAP9, OCEL1, and PPP2CA, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate mediated signaling activity versus AKAP9 in BLOOD_Leukemia (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AKAP9 →	+0.912	+0.264	.007	.002	3	3
BLOOD_Leukemia	OCEL1 →	-0.676	-0.278	.009	.001	3	2
CNS	PPP2CA →	+0.604	+1.432	.004	.008	3	2
CNS	TMEM106A →	+1.541	+1.117	<.001	.003	3	2
BREAST	TMEM109 →	-0.679	-0.441	.004	<.001	3	2
BREAST	KMT5C →	+1.351	+0.432	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009756 vs AKAP9 — BLOOD_Leukemia

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