Hormone-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Hormone-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CSRP1, RPS2, and BBS7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hormone-mediated signaling pathway activity versus CSRP1 in CCRCC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CSRP1 →	+0.729	+0.034	.004	<.001	3	6
BRCA	RPS2 →	-0.174	-0.028	<.001	<.001	3	6
BRCA	BBS7 →	+0.295	+0.029	.001	<.001	3	6
BRCA	EIF3H_S183 →	-0.440	-0.021	<.001	<.001	3	6
BRCA	ILK →	+0.418	+0.020	<.001	<.001	3	6
HNSC	CYGB →	+0.298	+0.034	.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009755 vs CSRP1 — CCRCC

Explore this scatter interactively →