Hormone-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Hormone-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOPORS, RPL30, and NSDHL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TOPORS grouped by Hormone-mediated signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TOPORS →	+0.252	+0.136	<.001	.002	3	6
OESOPHAGUS	RPL30 →	+0.570	+0.185	.005	.002	3	5
SOFT_TISSUE	NSDHL →	-0.158	-0.150	<.001	.004	3	4
LUNG_NSCLC_LUAD	KRR1 →	+0.347	+0.200	.001	.001	3	4
BLOOD_Leukemia	MTMR12 →	+0.181	+0.179	.002	.001	3	4
LUNG_NSCLC_LUAD	OR8D2 →	-0.192	-0.217	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TOPORS by Hormone-mediated signaling pathway activity — LUNG_SCLC

Explore this box plot interactively →