Hormone-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Hormone-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNK3, MLLT10, and PRKAB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hormone-mediated signaling pathway activity versus WNK3 in CNS (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	WNK3 →	+0.764	+0.239	<.001	<.001	3	6
STOMACH	MLLT10 →	+0.915	+0.118	.005	.007	3	5
BLOOD_Leukemia	PRKAB2 →	+0.891	+0.141	<.001	<.001	3	5
BLOOD_Leukemia	PAQR3 →	+0.979	+0.130	.001	.001	3	5
LIVER	ASNS →	+4.100	+0.165	.001	<.001	3	4
URINARY_TRACT	MYO10 →	-3.393	-0.175	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009755 vs WNK3 — CNS

Explore this scatter interactively →