Response to fructose

Across TCGA patient cohorts, RNA activity of the Response to fructose pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DYSF, GNAI2, and CYBB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to fructose activity versus DYSF in LSCC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DYSF →	+0.532	+0.079	<.001	<.001	3	6
LSCC	GNAI2 →	+0.321	+0.060	<.001	.004	3	6
PDAC	CYBB →	+0.628	+0.059	<.001	.001	3	6
GBM	ICAM3 →	+0.629	+0.079	<.001	<.001	3	6
GBM	MNDA →	+1.044	+0.089	<.001	<.001	3	6
LSCC	PPP1R18_S368 →	+0.747	+0.099	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009750 vs DYSF — LSCC

Explore this scatter interactively →