Response to fructose

Across TCGA patient cohorts, RNA activity of the Response to fructose pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP126, FPR1, and SLC2A5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to fructose activity versus CEP126 in BRCA (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CEP126 →	-0.775	-0.713	.003	.001	3	4
HNSC	FPR1 →	+0.645	+0.736	.007	<.001	3	4
CCRCC	SLC2A5 →	+1.209	+0.171	<.001	<.001	3	4
LUAD	AQP9 →	+0.512	+0.360	.005	.002	3	4
LUAD	LOXL2 →	+0.814	+0.402	.002	.001	3	4
LUAD	ADGRG3 →	+0.449	+0.296	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009750 vs CEP126 — BRCA

Explore this scatter interactively →