Response to fructose

Across TCGA cell cohorts, RNA activity of the Response to fructose pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEYL, CST3, and NOMO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HEYL grouped by Response to fructose-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HEYL →	+1.655	+0.264	.005	.004	3	4
OVARY	CST3 →	-0.904	-0.797	.005	.003	3	4
SKIN	NOMO1 →	-0.733	-1.200	.002	.002	3	3
SKIN	EMC10 →	-0.693	-0.909	.002	.005	3	3
SKIN	TAF1D →	+0.760	+1.237	.001	<.001	3	3
SKIN	AKTIP →	+0.555	+0.844	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HEYL by Response to fructose activity — LUNG_SCLC

Explore this box plot interactively →