Response to carbohydrate

Across TCGA patient cohorts, RNA activity of the Response to carbohydrate pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02739, MAGIX, and DEFB1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to carbohydrate activity versus LINC02739 in COAD (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINC02739 →	+0.260	+0.605	.002	.008	3	2
COAD	MAGIX →	+0.937	+0.845	<.001	.007	3	2
COAD	DEFB1 →	+2.155	+0.610	<.001	.007	3	1
COAD	SWI5 →	+0.431	+0.838	.001	.008	3	1
COAD	COPG1 →	-0.785	-0.326	.001	.001	3	1
COAD	IBA57-DT →	+0.738	+0.306	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009743 vs LINC02739 — COAD

Explore this scatter interactively →