Response to carbohydrate

Across TCGA cell cohorts, RNA activity of the Response to carbohydrate pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYH9, IRF1, and GADD45A, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to carbohydrate activity versus MYH9 in BONE (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MYH9 →	+2.421	+0.112	<.001	<.001	3	11
SOFT_TISSUE	IRF1 →	+2.565	+0.116	<.001	<.001	3	11
BREAST	GADD45A →	+2.185	+0.094	<.001	<.001	3	10
BONE	TGFBI →	+5.892	+0.127	<.001	<.001	3	10
SOFT_TISSUE	MTCH1 →	+0.917	+0.088	<.001	<.001	3	10
BONE	NLRC5 →	+2.016	+0.116	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009743 vs MYH9 — BONE

Explore this scatter interactively →