Response to carbohydrate

Across TCGA cell cohorts, RNA activity of the Response to carbohydrate pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSP90AB1, MRPS17, and ZNF133, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to carbohydrate activity versus HSP90AB1 in CNS (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HSP90AB1 →	-0.721	-0.186	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MRPS17 →	-0.855	-0.223	.007	.008	2	5
CNS	ZNF133 →	+0.580	+0.193	.004	<.001	3	4
LARGE_INTESTINE	RIC8B →	-0.535	-0.187	.004	.001	3	4
LIVER	MED31 →	-0.697	-0.308	<.001	.002	3	4
LIVER	DENND1A →	-0.823	-0.250	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009743 vs HSP90AB1 — CNS

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