Catechol-containing compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Catechol-containing compound biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D22B, MIF, and SLC35B2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBC1D22B grouped by Catechol-containing compound biosynthetic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TBC1D22B →	-0.181	-0.276	.005	.003	3	4
BREAST	MIF →	-0.120	-0.630	.004	<.001	3	3
PANCREAS	SLC35B2 →	-0.177	-0.990	<.001	<.001	3	3
BLOOD_Myeloma	JAK2 →	-0.380	-2.047	.001	<.001	3	3
LUNG_SCLC	TAAR5 →	-0.242	-1.323	.002	.004	3	3
LUNG_SCLC	TRAM1L1 →	+0.451	+1.478	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBC1D22B by Catechol-containing compound biosynthetic process activity — LIVER

Explore this box plot interactively →