Catechol-containing compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Catechol-containing compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTTG1, NSD3, and NSMAF, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Catechol-containing compound biosynthetic process activity versus PTTG1 in CNS (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PTTG1 →	+0.606	+1.643	.007	<.001	3	3
OESOPHAGUS	NSD3 →	+0.876	+1.740	.003	.002	3	2
OESOPHAGUS	NSMAF →	+1.396	+1.617	<.001	.001	3	2
BLOOD_Lymphoma	PTPA →	+1.023	+1.925	.002	<.001	3	2
BLOOD_Lymphoma	CLECL1 →	-3.330	-1.897	.002	<.001	3	2
OESOPHAGUS	GPR32 →	+0.054	+1.651	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009713 vs PTTG1 — CNS

Explore this scatter interactively →