Catechol-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Catechol-containing compound metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PA2G4, DNTTIP2, and EMG1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Catechol-containing compound metabolic process activity versus PA2G4 in UCEC (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PA2G4 →	-0.311	-0.078	<.001	<.001	3	8
GBM	DNTTIP2 →	-0.301	-0.039	<.001	<.001	3	8
BRCA	EMG1 →	-0.556	-0.049	<.001	<.001	3	8
GBM	SF3A1 →	-0.251	-0.049	<.001	<.001	3	8
GBM	SF3A2 →	-0.318	-0.049	<.001	<.001	3	8
GBM	TPR →	-0.235	-0.051	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009712 vs PA2G4 — UCEC

Explore this scatter interactively →