Catechol-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Catechol-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMPO, HAUS8, and COPS3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Catechol-containing compound metabolic process activity versus TMPO in UCEC (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMPO →	-0.607	-0.132	.002	.001	3	7
UCEC	HAUS8 →	-0.601	-0.133	<.001	<.001	3	7
LSCC	COPS3 →	-0.549	-0.162	.001	<.001	3	7
UCEC	RACGAP1 →	-0.796	-0.126	<.001	<.001	3	7
UCEC	NME1 →	-0.493	-0.158	.003	<.001	3	7
OV	UBE2N →	-0.444	-0.147	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009712 vs TMPO — UCEC

Explore this scatter interactively →