Catechol-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Catechol-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH2, MT1X, and COMT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Catechol-containing compound metabolic process activity versus ALDH2 in BREAST (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ALDH2 →	+2.825	+0.632	.001	.003	2	5
BLOOD_Myeloma	MT1X →	+2.606	+1.822	<.001	<.001	3	4
BLOOD_Lymphoma	COMT →	+0.880	+0.962	.005	.005	3	3
BLOOD_Leukemia	MTMR1 →	-0.832	-0.746	.004	.001	3	3
BREAST	GLRX5 →	-0.500	-0.700	.005	.005	3	3
BREAST	ACTL10 →	+0.775	+0.600	.003	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009712 vs ALDH2 — BREAST

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