Response to salt stress

Across TCGA cell cohorts, RNA activity of the Response to salt stress pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1B1, ARHGAP45, and ANO10, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to salt stress activity versus AKR1B1 in BLOOD_Leukemia (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AKR1B1 →	+3.173	+0.234	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	ARHGAP45 →	-1.313	-0.247	.002	.002	3	6
OESOPHAGUS	ANO10 →	+0.797	+0.236	.006	.006	3	5
BLOOD_Leukemia	KMT2E →	+0.971	+0.146	<.001	.001	3	5
LUNG_NSCLC_LUAD	AKR1C1 →	+4.548	+0.184	<.001	.002	3	4
BLOOD_Lymphoma	NEDD1 →	-0.660	-0.107	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009651 vs AKR1B1 — BLOOD_Leukemia

Explore this scatter interactively →