UV protection

Across TCGA patient cohorts, RNA activity of the UV protection pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFAP4, DMPK, and SPACA6, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UV protection activity versus MFAP4 in TGCT (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	MFAP4 →	+3.171	+0.087	<.001	<.001	3	26
SARC	DMPK →	+0.830	+0.022	<.001	.001	3	25
ACC	SPACA6 →	+1.021	+0.049	<.001	<.001	3	24
THYM	INAFM1 →	+0.748	+0.056	<.001	<.001	3	24
MESO	ERCC2 →	+0.606	+0.046	<.001	<.001	3	24
THYM	WTIP →	+0.837	+0.072	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009650 vs MFAP4 — TGCT

Explore this scatter interactively →