UV protection

Across TCGA patient cohorts, RNA activity of the UV protection pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF785, SOWAHD, and ZNF764, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UV protection activity versus ZNF785 in HNSC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF785 →	+0.436	+0.121	.009	.009	3	4
CCRCC	SOWAHD →	+0.326	+0.093	.009	.007	3	3
LSCC	ZNF764 →	+0.501	+0.181	<.001	.002	3	3
BRCA	ORAI3 →	+0.553	+0.159	.001	.003	2	4
PDAC	RNA5SP530 →	+0.341	+0.107	<.001	.003	3	3
PDAC	STX1B →	+0.201	+0.127	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009650 vs ZNF785 — HNSC

Explore this scatter interactively →