UV protection

Across TCGA patient cohorts, RNA activity of the UV protection pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAVIN2_T33, LIN54_S264, and MRTFA_S807, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UV protection activity versus CAVIN2_T33 in OV (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CAVIN2_T33 →	-1.615	-0.312	.001	<.001	3	3
PDAC	LIN54_S264 →	+0.587	+0.305	.003	<.001	3	3
UCEC	MRTFA_S807 →	+0.602	+0.174	<.001	<.001	3	3
OV	SEC24D_S266 →	-0.766	-0.236	<.001	<.001	3	2
OV	SIK3_T469 →	+0.657	+0.129	<.001	<.001	3	2
OV	SLTM_S815 →	-0.837	-0.221	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009650 vs CAVIN2_T33 — OV

Explore this scatter interactively →