UV protection

Across TCGA cell cohorts, RNA activity of the UV protection pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBPMS2, ANKRD6, and IGBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBPMS2 grouped by UV protection-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RBPMS2 →	+2.160	+1.368	<.001	<.001	3	5
SKIN	ANKRD6 →	+1.274	+1.000	.002	.002	3	4
PANCREAS	IGBP1 →	-0.751	-1.104	.004	.002	2	5
LUNG_NSCLC_LUSC	BHLHE41 →	-1.786	-1.455	.006	<.001	3	4
CNS	RAC3 →	+0.867	+0.737	.002	.005	3	4
LIVER	PARP4 →	-0.784	-1.630	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBPMS2 by UV protection activity — SOFT_TISSUE

Explore this box plot interactively →