UV protection

Across TCGA cell cohorts, RNA activity of the UV protection pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAT, MARS1, and PIR, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UV protection activity versus CAT in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CAT →	+1.445	+0.142	.003	.005	3	13
LUNG_NSCLC_LUSC	MARS1 →	-0.560	-0.080	.007	.009	3	7
SKIN	PIR →	+1.106	+0.119	<.001	<.001	3	6
LUNG_NSCLC_LUSC	CTSD →	+1.898	+0.120	<.001	<.001	2	7
LARGE_INTESTINE	CASP6 →	+0.895	+0.109	.002	.001	3	6
BREAST	GPX1 →	+3.544	+0.131	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009650 vs CAT — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →