UV protection

Across TCGA cell cohorts, RNA activity of the UV protection pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAT, BACE2, and SHROOM4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UV protection activity versus CAT in STOMACH (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CAT →	+1.275	+0.265	.002	.003	2	7
KIDNEY	BACE2 →	+1.948	+0.327	.001	.004	3	5
SKIN	SHROOM4 →	+1.335	+0.263	.001	<.001	3	5
SKIN	TCTE3 →	-0.567	-0.269	.001	.005	3	5
BONE	CFAP36 →	-0.884	-0.297	.002	<.001	3	5
OVARY	CXCL2 →	+2.851	+0.354	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009650 vs CAT — STOMACH

Explore this scatter interactively →