Entrainment of circadian clock

Across TCGA patient cohorts, RNA activity of the Entrainment of circadian clock pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMCN1, RPS2, and RRP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Entrainment of circadian clock activity versus HMCN1 in BRCA (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HMCN1 →	+0.415	+0.042	<.001	<.001	3	7
BRCA	RPS2 →	-0.184	-0.045	<.001	.001	3	6
BRCA	RRP1 →	-0.441	-0.046	<.001	<.001	3	6
BRCA	SRPK1_S51 →	-0.461	-0.035	<.001	<.001	3	6
PDAC	BIRC6 →	-0.157	-0.036	<.001	.002	3	6
BRCA	BUB1B_S543 →	-0.584	-0.048	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009649 vs HMCN1 — BRCA

Explore this scatter interactively →