Entrainment of circadian clock

Across TCGA patient cohorts, RNA activity of the Entrainment of circadian clock pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NSF, RPL32P5, and GALNT5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Entrainment of circadian clock activity versus NSF in HNSC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NSF →	-0.628	-0.171	.005	.002	2	5
LUAD	RPL32P5 →	+0.195	+0.182	.007	.008	3	3
UCEC	GALNT5 →	-0.794	-0.141	.003	.008	3	3
UCEC	TOMM5 →	+0.334	+0.099	.001	.005	3	3
UCEC	MIR17HG →	+0.593	+0.120	<.001	<.001	3	3
PDAC	TAGLN2P1 →	-0.391	-0.161	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009649 vs NSF — HNSC

Explore this scatter interactively →