Entrainment of circadian clock

Across TCGA cell cohorts, RNA activity of the Entrainment of circadian clock pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STC2, ITCH, and RRM2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STC2 grouped by Entrainment of circadian clock-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	STC2 →	+4.352	+1.485	<.001	.001	3	5
STOMACH	ITCH →	+1.231	+0.415	.001	.001	3	4
SOFT_TISSUE	RRM2B →	-1.208	-1.281	.002	.003	3	4
SOFT_TISSUE	MCAM →	+5.045	+1.503	<.001	.007	3	4
CNS	SNX15 →	+0.554	+0.575	<.001	.002	3	4
PANCREAS	TPRA1 →	+0.694	+0.205	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STC2 by Entrainment of circadian clock activity — SOFT_TISSUE

Explore this box plot interactively →