Entrainment of circadian clock

Across TCGA cell cohorts, RNA activity of the Entrainment of circadian clock pathway is significantly associated with the protein abundance of multiple proteins, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GNA11, GNB2, and GNAQ, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Entrainment of circadian clock activity versus GNA11 in SOFT_TISSUE (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GNA11 →	+1.523	+0.319	.001	<.001	2	14
LIVER	GNB2 →	+1.353	+0.244	.001	.007	3	10
LARGE_INTESTINE	GNAQ →	+0.930	+0.204	.001	<.001	3	10
SKIN	TMEM43 →	+0.966	+0.243	.001	.001	3	9
SKIN	NUP155 →	+0.554	+0.189	<.001	.004	3	9
SKIN	HNRNPH3 →	+0.640	+0.246	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009649 vs GNA11 — SOFT_TISSUE

Explore this scatter interactively →