Photoperiodism

Across TCGA patient cohorts, RNA activity of the Photoperiodism pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EEF2_T435, HYI, and RRP12_S1080, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Photoperiodism activity versus EEF2_T435 in BRCA (Pearson r = -0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EEF2_T435 →	-1.144	-0.122	<.001	<.001	3	7
BRCA	HYI →	+0.471	+0.047	<.001	<.001	3	7
LSCC	RRP12_S1080 →	-0.466	-0.056	<.001	<.001	3	7
BRCA	LARP4B →	-0.343	-0.048	<.001	<.001	3	7
GBM	STXBP1 →	+0.474	+0.034	.001	.003	3	6
BRCA	EIF4G1 →	-0.215	-0.037	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009648 vs EEF2_T435 — BRCA

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