Photoperiodism

Across TCGA cell cohorts, RNA activity of the Photoperiodism pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALCOCO1, MGAT4A, and MFGE8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Photoperiodism activity versus CALCOCO1 in LARGE_INTESTINE (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CALCOCO1 →	+1.059	+0.148	.003	.003	3	5
SKIN	MGAT4A →	-1.144	-0.328	<.001	<.001	3	5
BLOOD_Leukemia	MFGE8 →	+1.494	+0.367	.003	.007	3	5
LUNG_NSCLC_LUSC	SLC39A9 →	-0.627	-0.240	.005	.002	3	4
BLOOD_Leukemia	OPTN →	+1.529	+0.527	.001	.007	3	4
LIVER	TENT4B →	-0.567	-0.353	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009648 vs CALCOCO1 — LARGE_INTESTINE

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