Response to toxic substance

Across TCGA patient cohorts, RNA activity of the Response to toxic substance pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARRDC4, P2RY1, and CD58, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to toxic substance activity versus ARRDC4 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARRDC4 →	+0.683	+0.213	<.001	.001	3	3
COAD	P2RY1 →	+0.566	+0.150	.004	.002	3	3
BRCA	CD58 →	+0.565	+0.295	.001	<.001	3	3
BRCA	TSPAN2 →	+0.965	+0.242	<.001	<.001	3	3
BRCA	CMAHP →	+0.983	+0.179	<.001	.008	3	3
BRCA	EID3 →	+0.737	+0.312	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009636 vs ARRDC4 — BRCA

Explore this scatter interactively →