Response to toxic substance

Across TCGA cell cohorts, RNA activity of the Response to toxic substance pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A2, KIF2A, and AFAP1L2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to toxic substance activity versus S100A2 in BONE (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	S100A2 →	-3.916	-0.209	.003	.009	3	6
BLOOD_Myeloma	KIF2A →	-0.752	-0.231	.001	.001	3	6
LIVER	AFAP1L2 →	-2.998	-0.334	<.001	<.001	3	6
STOMACH	ACADS →	+1.117	+0.210	.001	.006	3	6
LIVER	MSANTD3 →	-1.337	-0.348	.005	.002	3	5
BREAST	MCEE →	+0.765	+0.193	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009636 vs S100A2 — BONE

Explore this scatter interactively →