Response to toxic substance

Across TCGA cell cohorts, RNA activity of the Response to toxic substance pathway is significantly associated with the protein abundance of multiple proteins, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSS, PGLS, and DDX18, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to toxic substance activity versus GSS in SKIN (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GSS →	+1.475	+0.206	<.001	<.001	3	14
STOMACH	PGLS →	+1.846	+0.333	<.001	<.001	3	14
STOMACH	DDX18 →	-0.862	-0.269	<.001	<.001	3	13
STOMACH	NANS →	+1.542	+0.286	.007	<.001	3	13
STOMACH	RNPEP →	+1.243	+0.211	<.001	.003	3	13
STOMACH	MATR3 →	-0.622	-0.251	.009	.003	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009636 vs GSS — SKIN

Explore this scatter interactively →